Promising treatment for patients with allergies and autoimmune diseases

For the millions of people with hyperactive or hypersensitive immune systems who feel their bodies are constantly struggling, researchers have now found clues to how our bodies can mistakenly defend themselves against the dangers they face.

Protein neurotic

From persistent allergies to life-threatening anaphylaxis and debilitating autoimmune diseases, the immune system that is supposed to protect us can be a problem for our health. Fortunately, researchers have come up with a method that can completely solve these problems.

Using genetically modified mice and cell cultures were taken from the tonsils, the researchers found evidence that our bodies are improperly protected, which leads to many diseases such as asthma, food allergies, lupus, etc. They found that the cause may be a protein called neuritis, which is produced by immune cells and acts to some extent as an antihistamine and is embedded in other factors.

Immunologist Paula Gonzalez from the Australian National University (ANU) explained: "There are more than 80 autoimmune diseases, many of which we find by antibodies that bind to our tissues and attack us instead of targeting pathogens such as viruses and bacteria. antibodies that fight our body, not invaders."

Immune-regulating T cells are known to suppress the body's self-targeting antibodies and immunoglobulin IgE, which induces the release of the notorious histamine in response to allergies, but it took Gonzalez and her team five years to figure out how to do this using genetically modified mice and human cells transplanted into the laboratory.

How was the experience?

Using a standard biological chain reaction method, a special class of cells called follicle regulators (or Tfr) injects neurotic, reducing the production of antihistamines and suppressing other processes that cause the production of antibodies attacking the body itself. The researchers found that mice unable to produce neurotic had an increased chance of dying from anaphylaxis when injected with albumin from an egg.

This is because these mice, which were genetically bred, lack cells that produce neurotic, Tfr, regulating follicles, and the population of defective plasma cells grew at the beginning of their life, and it was these cells that developed their antigens. However, when the group treated mice with Tfr deficiency by injecting neuritis into their veins, they recovered and resisted hypersensitivity.

Gonzalez and her colleagues write explaining that the treatment has led to surprising results regarding the health of sick mice. However, the team cautions that they do not yet fully understand the pathway in which these immune mechanisms are involved or the effect of neurotoxins on other cellular processes.

 While neuroticism has been studied in the human nervous system for some time, the exact way it triggers neurons has not been clear. To find out, white cells of human blood and tonsils were analyzed for the presence of the protein neurotoxin, which revealed evidence that it works, and the results may lead to a better understanding of how neurotics can be used in the future to treat immune diseases.

promising results

It may be more than just a new drug, it may be a completely new approach to the treatment of allergies and autoimmune diseases. When it is approved, there will be no need to deplete important immune cells or suppress the entire immune system; instead, we will need to use only those proteins that our body uses to ensure immune tolerance. Then millions of people suffering from allergies and autoimmune diseases will find peace in their tired bodies.